Functional Genomics

How It Works

Our functional genomics product addresses key problems you face when training AI models for early drug discovery: data availability, quality, and uniformity. We generate large, high fidelity transcriptomic and phenotypic datasets in the disease context of your choice.

We introduce genetic and chemical perturbations in major cell types and provide you with your readouts of choice. Our highly automated workflow means you get data back in as little as 3 weeks.

Select from a range of perturbations and readout types

Readouts	Measurements
DRUG-seq (high throughput bulk RNA-seq)	Transcript abundance
High Content Imaging	Images, fluorescence intensity
High Throughput Verify (Amp-seq)	Indel formation in the target gene
Perturbations	Type of perturbation
Arrayed	Chemical
Arrayed	Genetic CRISPRi / CRISPR KO - incl. siRNAs (lipofectamine transfection, lentiviral transduction)
Cell Models	Examples
Primary cells	iPSC-derived neurons, Fibroblasts
Standard cell lines	A549, HEK293, U20S, etc.
Co-cultures	Human + mouse neurons

Designed with your needs in mind

Flexibility & Customization

Bring your own cell line or choose one of ours. Select a compound library and your data readout preference.

Scale & Speed

10,000s of in vitro chemical and genetic perturbations in each cell type. All delivered in as little as 3 weeks.

Simple & Easy Terms

Fee-for-service only: no royalties, no milestones. And you own the data, always. Our version of an easy button.

Datasets

Interact with Sample Datasets

Details	GDPx3	GDPx2	GDPx1
DOWNLOAD NOW	Download GDPx3	Download GDPx2	Download GDPx1
RELEASE DATE	May 2025	December 2024	September 2024
DATA PACKAGE	Metadata for a subset of 7 test compounds and 6 controls PDF outlining the experimental setup PDF outlining the data analysis pipeline steps	Metadata for a subset of 10 compounds and all controls PDF outlining the experimental set up	Metadata for the 1264 compounds screen Raw UMI counts for the subset of 20 compounds PDF outlining the experimental set up
CELL TYPES	A549 cells (human non-small cell carcinoma epithelial cell line) aortic smooth muscle cells dermal fibroblast aortic endothelial cells	Human melanocytes cells aortic smooth muscle cells dermal fibroblast skeletal muscle myoblasts	A549 cells (human non-small cell carcinoma epithelial cell line)
PERTURBATIONS	46 compounds total: 40 compounds, 4 concentrations, 2 time points, 4 replicates + 6 controls	85 compounds, 6 concentrations, 4 replicates	1,264 compounds, 2 concentrations, 4 replicates
READOUT	High Content Imaging (Cell Painting) with 2200 x 2200 image dimensions	Transcriptomic (DRUG-seq) with 2M reads sequencing depth	Transcriptomic (DRUG-seq) with 2M reads sequencing depth
PLATE DENSITY	384 well plate	384 well plate	384 well plate
AVAILABLE DATASET SIZE	~55 GB / cell type compressed, 100 GB uncompressed	~200 GB / cell type	60 GB

How It Works

Select from a range of perturbations and readout types

Designed with your needs in mind

Interact with Sample Datasets

Need data? Let's talk.