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Antibody Developability
Functional Genomics
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Antibody Developability
Functional Genomics
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Overview

Functional Genomics

GDPx3
GDPx2

Antibody Developability

GDPa1
Datasets

Datasets

Overview

Functional Genomics

GDPx3
GDPx2

Antibody Developability

GDPa1
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Products

Antibody Developability
Functional Genomics
Products

Products

Antibody Developability
Functional Genomics
Contact Us

Datasets

Overview

Functional Genomics

GDPx3
GDPx2

Antibody Developability

GDPa1
Datasets

Datasets

Overview

Functional Genomics

GDPx3
GDPx2

Antibody Developability

GDPa1
Contact Us

Select by Type

All Resources
Blog Posts
Resources

Select by Type

All Resources
Blog Posts
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Biophysical Characterization Data

Antibody Developability

We generate biophysical antibody characterization developability datasets for you to use in AI model training and validation. Our world-class wet lab infrastructure offers you the scale and breadth you need to unlock AI for antibody developability.

Download Sample Data

How It Works

We take your antibody sequences as input, perform wet lab workflows in high-throughput, and return AI-ready datasets as output. We synthesize, express, and purify the antibodies, perform broad biophysical characterization, analyze and integrate the data, and return an AI-ready dataset to you.

We offer multiple biophysical readouts at scale

Standard AssaysTechnologyData Output

Titer

Valita

mg/L

Target Binding

BLI

KD

Fragmentation (CE-SDS)

LabChip

%Purity

Aggregation (SEC)

HPLC

%HMW, %Monomer

FcRn Binding

BLI

KD

Heparin Binding (HAC)

HPLC

RT

Polyreactivity (CHO or Ova)

PSP, BLI

Polyreactivity Score

Functional Cell-Based Assay

(Target dependent custom assay onboarding required)

Assay Dependent

Assay Dependent 

Thermostability

DSF, nanoDSF

Tm, Tonset

Self-Association (AC-SINS)

AuNP-based

Δλmax

Hydrophobicity (HIC)

HPLC

RT

Colloidal Stability (SMAC)

HPLC 

RT

Self-Interaction (DLS-kD)

(DLS-kD requires more purified antibody)

DynaPro III

kD

Designed with your needs in mind

01

Breadth & Scale

Screen 2,400+ antibody sequences in parallel across 10+ assays targeting key biophysical properties, powered by our >$1 billion Boston wet lab infrastructure.

02

AI-ready Data & AI Expertise

Generate AI-ready data through our standardized screening platform, powered by our team of AI and biophysics experts and proprietary software.

03

Simple & Easy Terms

Fee-for-service only: no royalties, no milestones. And you own the data, always. Our version of an easy button.

Datasets

Interact with Sample Data

DETAILSGDPa1

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Download GDPa1

PREPRINT

Read the preprint with method details, results summary, and discussion

DATA PACKAGE

  • 246 IgGs were characterized by the biophysical assays listed below.

  • Data readouts are reported for each antibody that was tested for each assay and passed quality control criteria for that assay.

  • Data is available in a tidy data format

ANTIBODY PRODUCTION

Antibodies were expressed in HEK293F and purified using Protein A chromatography prior to developability assessment for all assays. Antibodies tested on DLS-kD went through an additional polishing SEC step. A smaller subset of antibodies (20 IgGs) was produced in ExpiCHO and purified using Protein A chromatography. 

DEVELOPABILITY ASSAYS

  1. Titer by Valita

  2. Purity by rCE-SDS

  3. Aggregation by SEC

  4. Thermostability by nanoDSF and DSF

  5. Colloidal stability by SMAC

  6. Hydrophobicity by HIC

  7. Heparin binding by HAC 

  8. Self association by AC-SINS

  9. Self association by DLS-kD

  10. Polyreactivity by bead-based method against CHO SMP and ovalbumin

DATASHEETS IN DATA FILE

  • Definitions of column headers in other datasheets

  • Antibody sequences

  • Assay data in “tidy data” format with one row per replicate

  • Assay data summary statistics with average, standard deviation, and replicates for each assay

  • Data for nanodsf vs dsf with the same ramp rate in “tidy data” format

  • Prior literature data summarizing prior published results compared with GDPa1 data in the associated preprint

Download GDPa1

This dataset contains antibody developability data for a set of 246 IgG antibodies characterized by 10 assays. The antibodies tested include approved, clinical-stage, and preregistration molecules. Read the full GDPa1 preprint here and see below for terms of use

By clicking ‘Download’ and accessing the dataset included therein (the “data”) you acknowledge and agree that: (1) the data is solely owned by Ginkgo Bioworks, Inc. and/or its affiliates and/or representatives (collectively, “Ginkgo”) and you are not granted any license thereto except solely as necessary for the limited purpose of determining whether to pursue a data generation agreement with Ginkgo (“the Purpose”) and for no other purpose; (2) you may not copy, modify, sell, lease, or distribute the data (except as necessary for the Purpose); (3) in no event will Ginkgo be liable to you or any third party for any consequential, special, indirect, incidental, punitive or exemplary damages, costs, expenses or losses (including lost profits) (collectively, “damages”), regardless of the form of action or the basis for such claim or liability arising in any way from your access to or use of the data; and (4) Ginkgo does not make any representations, warranties or guarantees of any kind with respect to the data, either express or implied, including any warranty of quality, merchantability, or fitness for a particular use or purpose or any warranty as to non-infringement of any intellectual property rights of third parties.

Read the Preprint

Tell us what data you need. We’ll generate a large antibody developability dataset to power your AI model.

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