Antibody Developability

DNA sequences for each IgG were synthesized and transfected into HEK293F cells. Expressed IgGs were purified with protein-A-based resins then characterized with the following developability assays: thermostablity by nanoDSF, aggregation by SE-HPLC, colloidal stability by SMAC, Hydrophobicity by HI-HPLC, Self association by AC-SINS. The downloadable dataset includes assay parameters and data output for each of the above assays. There is also a readme file with more details on the assays and descriptions of each of the fields in the dataset.

By clicking ‘Download’ and accessing the dataset included therein (the “data”) you acknowledge and agree that: (1) the data is solely owned by Ginkgo Bioworks, Inc. and/or its affiliates and/or representatives (collectively, “Ginkgo”) and you are not granted any license thereto except solely as necessary for the limited purpose of determining whether to pursue a data generation agreement with Ginkgo (“the Purpose”) and for no other purpose; (2) you may not copy, modify, sell, lease, or distribute the data (except as necessary for the Purpose); (3) in no event will Ginkgo be liable to you or any third party for any consequential, special, indirect, incidental, punitive or exemplary damages, costs, expenses or losses (including lost profits) (collectively, “damages”), regardless of the form of action or the basis for such claim or liability arising in any way from your access to or use of the data; and (4) Ginkgo does not make any representations, warranties or guarantees of any kind with respect to the data, either express or implied, including any warranty of quality, merchantability, or fitness for a particular use or purpose or any warranty as to non-infringement of any intellectual property rights of third parties.